Status:
COMPLETED
A Study to Test the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of MK1006 (MK-1006-002)(COMPLETED)
Lead Sponsor:
Merck Sharp & Dohme LLC
Conditions:
Type 2 Diabetes Mellitus
Eligibility:
All Genders
18-55 years
Phase:
PHASE1
Brief Summary
This study will assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of single doses of MK1006
Eligibility Criteria
Inclusion
- Participant is between 18 and 55 years of age. Participants up to 65 years of age may be enrolled in Panels B and C
- Female participants must be postmenopausal or otherwise unable to have children
- Participant has a body mass index (BMI) less than or equal to 42 kg/m\^2 at the screening visit
- Participant has type 2 diabetes and is being treated with either diet and exercise or a single oral anti-hyperglycemic medication. For Panels B and C, participant may be treated with combination oral anti-hyperglycemic medications
- Participant is willing to follow the American Heart Association (AHA) diet and exercise program throughout the study
- Participant is a nonsmoker or has not used nicotine-containing products for 6 months prior to study start
Exclusion
- Participant has a history of stroke, seizures, or other neurological disorders
- Participant has a recent history of eye infection or other inflammatory eye conditions
- Participant has glaucoma or is blind
- Participant has had eye surgery within 6 months of study start (Lasik is permitted)
- Participant has type 1 diabetes
- Participant cannot stop taking any of their current prescription or non-prescription medications during the study
- Participant consumes more than 3 alcoholic beverages per day
- Participant consumes more than 6 caffeinated beverages per day
- Participant has had major surgery or has donated blood within 4 weeks of study start
- Participant has multiple and/or severe allergies to drugs or food
Key Trial Info
Start Date :
April 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2008
Estimated Enrollment :
25 Patients enrolled
Trial Details
Trial ID
NCT00757601
Start Date
April 1 2008
End Date
December 1 2008
Last Update
February 5 2016
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