Status:
COMPLETED
Electroencephalography (EEG) Biomarkers of Response in Depression
Lead Sponsor:
University of California, Los Angeles
Collaborating Sponsors:
Medtronic - MITG
Wyeth is now a wholly owned subsidiary of Pfizer
Conditions:
Major Depressive Disorder
Eligibility:
All Genders
18-65 years
Phase:
PHASE4
Brief Summary
There are two specific aims of this project: 1. To identify physiologic indicators of venlafaxine treatment response using quantitative EEG (QEEG) cordance, and to determine if cordance changes are s...
Detailed Description
Our previous work indicates that a combination of neurophysiologic, symptom, and cognitive measures may predict response more accurately than brain functional measures alone. The purpose of this study...
Eligibility Criteria
Inclusion
- All subjects will meet DSM-IV criteria for depression on the basis of a SCID-P interview, with subjects having a score on the 17-item Ham-D \> 17 (with item #1 \> 2).
- Subjects will meet criteria both at recruitment and after a one-week single blind placebo wash-in. Study includes outpatients only.
Exclusion
- All subjects will have no serious medical illness. The investigators will exclude patients also meeting criteria for the following groups of axis I diagnoses:
- delirium or dementia
- substance-related disorders
- schizophrenia or other psychotic disorders, or eating disorders.
- In addition, patients meeting criteria for cluster A or B axis II diagnoses will be excluded.
- Subjects with a history of current or past active suicidal ideation, or suicide attempts will be excluded from the study.
Key Trial Info
Start Date :
November 1 2002
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2005
Estimated Enrollment :
44 Patients enrolled
Trial Details
Trial ID
NCT00759122
Start Date
November 1 2002
End Date
December 1 2005
Last Update
September 25 2008
Active Locations (1)
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1
UCLA Laboratory of Brain, Behavior, and Pharmacology
Los Angeles, California, United States, 90024