Status:
RECRUITING
Circulating Markers That Underlie the Transition From Compensated Hypertrophy to Heart Failure
Lead Sponsor:
UConn Health
Collaborating Sponsors:
CT Department of Public Health
Conditions:
Acute Decompensated Heart Failure
Heart Failure
Eligibility:
All Genders
18+ years
Brief Summary
The purpose of this research is to determine if two proteins in the blood are increased during acute heart failure. These two proteins are produced when the heart becomes dysfunctional and unable to c...
Detailed Description
Heart failure (HF) is a complex clinical syndrome and major public health problem claiming the lives of \>500,000 per year. It is the leading Diagnosis Related Group (DRG) for hospital discharges in t...
Eligibility Criteria
Inclusion
- Individuals aged \>18yrs
- stable or decompensated heart failure, irrespective of LVEF
- decompensated heart failure clinical symptoms such as dyspnea, rales, edema, elevated jugular venous pressure, or ascites
- Imaging evidence of heart failure (cardiomegaly, poor contractile function or echocardiographic Doppler evidence of diastolic dysfunction or elevated right- or left-sided filling pressures)
- Healthy individuals with no prior history of heart attack or heart failure will be recruited to use as controls.
Exclusion
- Subjects who are unable to give informed consent
- Subjects who had undergone cardiac or non-cardiac surgery in the 3 months before enrollment
- Pregnant subjects are not excluded
Key Trial Info
Start Date :
December 1 2005
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2027
Estimated Enrollment :
500 Patients enrolled
Trial Details
Trial ID
NCT00762008
Start Date
December 1 2005
End Date
December 1 2027
Last Update
August 12 2025
Active Locations (1)
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1
University of Connecticut Health Center
Farmington, Connecticut, United States, 06030