Status:
COMPLETED
Study of the Medication Prazosin for Alcohol Dependence
Lead Sponsor:
Seattle Institute for Biomedical and Clinical Research
Collaborating Sponsors:
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
VA Puget Sound Health Care System
Conditions:
Alcoholism
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
The purpose of this study is to determine whether the drug prazosin is effective for the treatment of alcohol dependency.
Detailed Description
Alcohol dependence (AD) afflicts nearly 10% of the US population and causes marked medical morbidity and mortality, marked psychiatric morbidity, increased health care costs, and lost work hours (Saxo...
Eligibility Criteria
Inclusion
- Current primary DSM-IV diagnosis of alcohol dependence(AD)
- Heavy drinking in the last 30 days
- At least 18 years of age
- Good general medical health (see Exclusion Criteria below)
- Capacity to provide informed consent
- English fluency and literacy
Exclusion
- Psychiatric/behavioral: current post-traumatic stress disorder(PTSD); psychiatric disorder requiring any medication other than anti-depressants; currently taking disulfiram, acamprosate, or naltrexone or planning to take any of these medications during the 12-week medication phase of the study; current dependence on any other psychoactive substance other than nicotine or cannabis; a current diagnosis of opioid abuse, use of any opioid- containing medications or benzodiazepines during the previous month, or UDA positive for opioids, benzodiazepines, or sedative hypnotics.
- Medical: significant acute or chronic medical illness; women who are pregnant, nursing infant(s), or of childbearing potential and not using a contraceptive method judged by the study physician or PA to be effective; signs or symptoms of alcohol withdrawal at the time of initial consent
- Legal involvement that could interfere with study treatment. Individuals court ordered for treatment will not be eligible to participate in this study.
Key Trial Info
Start Date :
January 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2014
Estimated Enrollment :
92 Patients enrolled
Trial Details
Trial ID
NCT00762710
Start Date
January 1 2008
End Date
June 1 2014
Last Update
June 4 2020
Active Locations (1)
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1
VA Puget Sound Health Care System
Seattle, Washington, United States, 98108