Status:
TERMINATED
Comparison of Dobutamine and Regadenoson Stress Cardiac Magnetic Resonance (MR)
Lead Sponsor:
Wake Forest University Health Sciences
Collaborating Sponsors:
Astellas Pharma US, Inc.
Conditions:
Coronary Artery Disease
Asthma
Eligibility:
All Genders
40-85 years
Phase:
EARLY_PHASE1
Brief Summary
The goal of this research is to determine the utility of Regadenoson (Lexiscan)for use as an imaging agent with cardiac MR. If found useful, it will help us establish a protocol for regadenoson stress...
Eligibility Criteria
Inclusion
- Men and women aged 40 to 85 years with OBSTRUCTIVE AIRWAY DISEASES (ASTHMA AND COPD) and a forced expiratory volume (FEV1) \> 0.5.
- Patients should have a clinical indication to undergo cardiac stress test with dobutamine.
Exclusion
- Those with pacemakers, defibrillators, functioning neural stimulator devices or other implanted electronic devices.
- Ferromagnetic cerebral aneurism clips or other intraorbital and intracranial metal.
- An allergy to Gadolinium or other severe drug allergies.
- Acute myocardial infarction within 3 months.
- Moderate or severe aortic stenosis or other significant valvular disease;
- Claustrophobia.
- High grade (2o or 3o) AV Block.
- Closed angle glaucoma.
- Participants unable to provide informed consent.
- Renal dialysis (subjects with moderate-to-severe renal impairment defined as eGFR \< 60 mL/min.
- A contraindication to receipt of dobutamine.
- Participants with known coronary artery disease will be included with the exception that patients with left main or narrowings \>50% in the distributions of the left anterior descending, circumflex, and right coronary artery will be excluded.
Key Trial Info
Start Date :
January 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2011
Estimated Enrollment :
14 Patients enrolled
Trial Details
Trial ID
NCT00763035
Start Date
January 1 2009
End Date
March 1 2011
Last Update
September 26 2018
Active Locations (1)
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1
WAKE FOREST UNIVERSITY Baptist Medical Center
Winston-Salem, North Carolina, United States, 27157