Status:
COMPLETED
Inflammation and Insulin Resistance in Rheumatoid Arthritis
Lead Sponsor:
Vanderbilt University
Collaborating Sponsors:
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Conditions:
Rheumatoid Arthritis
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Rheumatoid arthritis (RA) is a form of arthritis that causes pain, swelling, stiffness, and loss of function in the joints. Over time, joint deformity, joint destruction, and loss of function can occu...
Detailed Description
RA is an autoimmune disease that causes long-term inflammation of the joints and sometimes other body tissues, too. Recent studies have found that there is an increased prevalence of coronary artery a...
Eligibility Criteria
Inclusion
- Meets the American College of Rheumatology (ACR) criteria for the diagnosis of rheumatoid arthritis (RA)
- Stable disease activity, as evidenced by no change in immunomodulating or anti-inflammatory therapy in the 1 month before study entry
- Moderate disease activity, as reflected by a minimum of three swollen and tender joints
- If female of childbearing potential, willing to use effective method of contraception
Exclusion
- Allergic to pioglitazone
- Active cancer (other than skin cancer)
- HIV infected
- Currently receiving dialysis
- Received an organ or bone marrow transplant
- Heart failure
- Severe edema, as judged by the principal investigator
- Diabetes mellitus requiring drug therapy: levels of aspartate aminotransferase (AST) or alanine aminotransferase (ALT) greater than twice the upper limit of normal
- Underwent major surgery in the 3 months before study entry
- Severe comorbid condition that is likely to compromise survival or study participation
- Currently receiving gemfibrozil or rifampin
- Osteoporosis and not receiving osteoporosis medications
- Unwillingness, or other inability, to cooperate with study procedures
- Pregnancy
Key Trial Info
Start Date :
April 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2013
Estimated Enrollment :
34 Patients enrolled
Trial Details
Trial ID
NCT00763139
Start Date
April 1 2009
End Date
December 1 2013
Last Update
November 13 2014
Active Locations (1)
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1
Vanderbilt Clinical Research Center
Nashville, Tennessee, United States, 37232-2195