Status:
TERMINATED
Chronotherapy in Acute Multiple Sclerosis (MS) Attack
Lead Sponsor:
Sykehuset Innlandet HF
Conditions:
Multiple Sclerosis
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The Immunological system is showing a diurnal rhythmicity. The Mediators that enhances inflammation are at highest level during the night. At the same time the endogenous production of cortisol is at ...
Eligibility Criteria
Inclusion
- Relapsing remitting MS
- EDSS-score before the actual attack \< 6.0
- Acute MS-attack with indication for treatment with steroids
- Symptoms \>24 hours \< 4 weeks
- Age 18 years or older
Exclusion
- Prior enrollment in this study
- Ongoing serious infection that is a contraindication for treatment with steroids
- Pregnancy
- Medical situations (prior acute diseases) where treatment with intravenous steroids over short period of time is contraindicated or not favorable.
- Enhanced cognitive dysfunction
- Treatment with p.o or i.v steroids within 3 weeks prior to date of inclusion
Key Trial Info
Start Date :
April 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2012
Estimated Enrollment :
57 Patients enrolled
Trial Details
Trial ID
NCT00764413
Start Date
April 1 2009
End Date
July 1 2012
Last Update
November 24 2014
Active Locations (1)
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1
Innlandet Hosptal Trust-Lillehammer, Neurological Department
Lillehammer, Oppland, Norway, 2609