Status:
COMPLETED
Elucidation and Monitoring Postprandial Endothelial Function
Lead Sponsor:
Wageningen University
Collaborating Sponsors:
Top Institute Food and Nutrition
Conditions:
Cardiovascular Disease
Endothelial Dysfunction
Eligibility:
MALE
18-30 years
Phase:
NA
Brief Summary
The primary aim of this study is to evaluate the effect of a high fat challenge on several measures of endothelial function. The secondary aim of this study is to elucidate the mechanism of postprandi...
Detailed Description
Endothelial dysfunction (ED) is a hallmark for the initial stage of vascular dysfunction and has been associated with diet-related disorders such as cardiovascular disease. This makes prevention of ED...
Eligibility Criteria
Inclusion
- male, caucasian
Exclusion
- • Allergic to cow milk or dairy products
- Body mass index (BMI) \< 18 or \> 25 kg/m2
- Urine glucose concentrations outside normal ranges (\>0,25 g/l)
- Fasting blood glucose outside the normal range (3 - 5.5 mmol/L)
- Tobacco smoking
- Taking medication or food supplements.
- Received inoculations within 2 months of starting the study or planned to during the study
- Donated or intended to donate blood from 2 months before the study till two months after the study
- Blood Hb values below 8.4 mmol/L
- Diagnosed with any long-term medical condition (e.g., diabetes, hemophilia, cardiovascular disease, anemia, gastrointestinal disease, renal failure)
- High blood pressure (systolic BP\> 140 mmHg and/or diastolic BP\>90 mmHg)
Key Trial Info
Start Date :
October 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 1 2009
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00766623
Start Date
October 1 2008
End Date
March 1 2009
Last Update
September 29 2009
Active Locations (1)
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1
Wageningen universiteit division of human
Wageningen, Gelderland, Netherlands, 6703HD