Status:
COMPLETED
Endoscopic Variceal Ligation (EVL)+ Drugs Versus Endoscopic Variceal Ligation (EVL) Alone For Secondary Prophylaxis
Lead Sponsor:
Govind Ballabh Pant Hospital
Conditions:
Portal Hypertension
Eligibility:
All Genders
8-75 years
Phase:
NA
Brief Summary
Background: Both endoscopic variceal ligation (EVL) and propranolol are valuable methods for secondary prophylaxis of variceal bleeding. Addition of ISMN to propranolol improves the efficacy of drug t...
Eligibility Criteria
Inclusion
- Patients presenting to G B Pant Hospital, New Delhi, with history of hematemesis and/or melena and proven to have esophageal varices as the bleeding source on upper GI endoscopy were included in the study.
Exclusion
- A history of undergoing endoscopic sclerotherapy (EST), EVL, or cyanoacrylate injection;
- A history of surgery for portal hypertension;
- Coexisting malignancy;
- Severe cardiopulmonary or renal disease;
- A history of severe side-effects or contraindications to beta-blockers like bronchial asthma, uncontrolled diabetes mellitus, heart failure, peripheral vascular disease, prostatic hypertrophy, arterial hypotension (systolic blood pressure \< 100 mm Hg), bradycardia (basal heart rate \<55 beats per minute), or complete heart block; and
- Refusal to give consent to participate in the trial.
Key Trial Info
Start Date :
October 1 2002
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2007
Estimated Enrollment :
177 Patients enrolled
Trial Details
Trial ID
NCT00766805
Start Date
October 1 2002
End Date
June 1 2007
Last Update
October 6 2008
Active Locations (1)
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1
Department of Gastroenterology, G B Pant Hospital
New Delhi, National Capital Territory of Delhi, India, 110002