Status:
UNKNOWN
Early Cardiac Computed Tomography (CT) In Patients Admitted With Acute Chest Pain
Lead Sponsor:
Chelsea and Westminster NHS Foundation Trust
Collaborating Sponsors:
Royal Brompton & Harefield NHS Foundation Trust
British Heart Foundation
Conditions:
Acute Chest Pain
Eligibility:
All Genders
40+ years
Phase:
NA
Brief Summary
This is a randomised trial comparing early Cardiac Computed Tomography (CCT) to current standard practice for diagnosis of acute chest pain in patients at low to intermediate risk of having coronary a...
Detailed Description
Coronary Artery Disease (CAD) kills more people in the UK than any other condition, and causes symptoms of angina (chest pain) in many more. Acute chest pain accounts for approximately 600,000 NHS adm...
Eligibility Criteria
Inclusion
- Admission with suspected cardiac chest pain
- \>40 years of age
- EITHER Low likelihood of CAD according to DFC and troponin\>0.03 but \<3 OR Intermediate likelihood of CAD according to DFC
- Written informed consent
Exclusion
- ECG consistent with acute myocardial infarction (ST elevation, new left bundle branch block)
- Ongoing chest pain with dynamic ECG changes
- Haemodynamic or respiratory instability
- Serum troponin ≥3
- Previous percutaneous coronary intervention or coronary artery bypass grafting
- Admission to hospital between 5pm Friday and 9am Sunday
- Contraindication to negative chronotropic agents
- Maximum heart rate \>70bpm (including after pharmacologic treatment)
- Renal dysfunction (Creat\>150 micromol/l)
- Pregnancy or childbearing potential
- Allergy or previous intolerance of iodinated contrast
Key Trial Info
Start Date :
January 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2011
Estimated Enrollment :
250 Patients enrolled
Trial Details
Trial ID
NCT00767065
Start Date
January 1 2009
End Date
December 1 2011
Last Update
October 6 2008
Active Locations (1)
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1
Chelsea and Westminster Hospital
London, United Kingdom, SW10 9NH