Status:
COMPLETED
The Effect of Intravenous Anesthetics on Fear Learning and Memory
Lead Sponsor:
Weill Medical College of Cornell University
Collaborating Sponsors:
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Conditions:
Phobias
Eligibility:
All Genders
18-50 years
Phase:
NA
Brief Summary
People often develop fearful responses to things, but have no conscious control over the fear. This is a basic form of unconscious memory, called "fear conditioning." Intravenous anesthetic drugs have...
Detailed Description
People often develop fearful responses to things, but have no conscious control over the fear (e.g. phobias). This is a basic form of unconscious memory, called "fear conditioning." Intravenous anesth...
Eligibility Criteria
Inclusion
- age between 18 and 50
- minimum of high school education
- fluent in English
- normal vocabulary
Exclusion
- any significant medical or psychiatric comorbidity (e.g. asthma, diabetes, hypertension, depression, high anxiety)--subjects must be in excellent health such that they would be classified as American Society of Anesthesiologists Physical Status Class I
- deficit in vision or hearing that would impede the study
- allergies to any of the study drugs, to soybeans, or to eggs
- a history of head trauma
- a family history of major psychiatric illness
- body mass index \> 30 kg/m2
- a recent history of recreational drug use
- prior exposure to the study materials
- pregnancy
- a personal or family history of any porphyria
- failure to exhibit a skin conductance response to deep inspiration
- the ability to read Chinese characters
- assessment by the investigators that the subject may be unable to cooperate or comply with the study requirements.
Key Trial Info
Start Date :
October 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2011
Estimated Enrollment :
67 Patients enrolled
Trial Details
Trial ID
NCT00767767
Start Date
October 1 2008
End Date
May 1 2011
Last Update
May 15 2019
Active Locations (1)
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1
Weill Cornell Medical College/New York Presbyterian Hospital
New York, New York, United States, 10065