Status:
COMPLETED
Combined Pharmacotherapies for Alcoholism
Lead Sponsor:
Bankole Johnson
Collaborating Sponsors:
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Conditions:
Alcoholism
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
This study would like to test whether the combination of ondansetron and naltrexone will be superior to either medication alone or placebo in the treatment of alcohol dependence.
Detailed Description
We propose to conduct a 13 week randomized, controlled clinical trial to evaluate the safety and efficacy of ondansetron and naltrexone alone and in combination.Eligible subjects will be randomized to...
Eligibility Criteria
Inclusion
- Males and females who have given written informed consent.
- Ages 18 years and above and must weigh at least 40 kg and no more than 140 kg.
- Good physical health as determined by a complete physical examination, an EKG within normal limits, and laboratory screening tests within acceptable parameters (see exclusion criteria).
- Current DSM-IV diagnosis of alcohol dependence
- AUDIT score of equal or more than 8.
- Currently drinking
- Provide evidence of stable residence in the last month prior to enrollment in the study, and have no plans to move in the next three months.
- The pregnancy test for females at intake must be negative. Additionally, women of childbearing potential must be using an acceptable form of contraception. These include: oral contraceptives, hormonal (levonorgestrel) or surgical implants, or barrier plus spermicide.
- Literate in English and able to read, understand, and complete the ratings scales and questionnaires accurately, follow instructions, and make use of the behavioral treatments.
- Answer an advertisement in the newspaper/radio/television, or be referred from a health care professional and express a wish to stop drinking.
- Willingness to participate in behavioral treatments for alcoholism.
Exclusion
- Any current axis I DSM IV psychiatric disorder other than alcohol or nicotine dependence
- Elevation of liver enzymes - (SGOT), serum glutamic pyruvic transaminase (SGPT), blood urea nitrogen (BUN), or lactate dehydrogenase (LDH) greater than four times the normal range, or clinically significant elevated direct bilirubin as deemed by the principal investigator.
- Severe alcohol withdrawal symptoms which in the physicians opinion requires inpatient treatment.
- Serious medical co-morbidity requiring medical intervention or close supervision, or any condition which can interfere with the receipt of ondansetron.
- Severe or life-threatening adverse reactions to medications in the past or during this clinical trial.
- Female patients who are pregnant, lactating, or not adhering to an acceptable form of contraception at any time during the study.
- Received inpatient or outpatient treatment for alcohol dependence within the last 30 days (support groups such as AA are not exclusionary).
- Compelled to participate in an alcohol treatment program to maintain their liberty.
- Members of the same household.
- Concurrent treatment with any medications having a potential effect on alcohol consumption and related behaviors, or mood. These include: opiate antagonist (e.g. naltrexone), glutamate antagonists (e.g., acamprosate), serotonin re-uptake inhibitors (e.g. fluoxetine), serotonin antagonists (e.g. ritanserin or buspirone), other antidepressants (e.g. tricylic antidepressants or monoamine oxidase inhibitors), dopamine antagonists (e.g. haloperidol), calcium channel antagonists (e.g. isradipine), or compounds with actions similar to disulfiram (antabuse) or nicotine.
- Before double-blind randomization, urine must be free of opiates, cocaine, amphetamines, barbiturates, benzodiazepines, prescription and non-prescription drugs.
- Pyrexia of unknown origin
Key Trial Info
Start Date :
September 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2012
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT00768508
Start Date
September 1 2008
End Date
December 1 2012
Last Update
March 15 2013
Active Locations (2)
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1
UVA CARE
Charlottesville, Virginia, United States, 22911
2
UVA CARE Richmond
Richmond, Virginia, United States, 23294