Status:
TERMINATED
Effects of Statins on Lower Extremity Arterial Function Assessed by Magnetic Resonance Imaging
Lead Sponsor:
Johns Hopkins University
Collaborating Sponsors:
Pfizer
Conditions:
Diabetes
Eligibility:
All Genders
40-90 years
Phase:
NA
Brief Summary
Cholesterol-lowering drugs called statins improve the functioning of the endothelium, and help prevent heart disease. The investigators are testing whether statins improve endothelial function more in...
Detailed Description
Correct
Eligibility Criteria
Inclusion
- Age 40-90
- Male or female
- Type 2 diabetes
Exclusion
- Known pregnancy or nursing.
- Females of child bearing potential must have been surgically sterilized or be post menopausal.
- Smoking
- Known vascular disease
- Inability to complete MRI scan
- Symptoms of claudication
- Use of a nitrate medicine
- Use of any cholesterol-lowering agent
- LDL \< 70
- Acute illness
- Liver disease
- Contraindication to getting an MRI scan (i.e. electronic implant, shrapnel, cerebral aneurysm clip, welding history).
Key Trial Info
Start Date :
June 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2012
Estimated Enrollment :
16 Patients enrolled
Trial Details
Trial ID
NCT00770679
Start Date
June 1 2008
End Date
July 1 2012
Last Update
September 13 2017
Active Locations (1)
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1
Harry SIlber, MD
Baltimore, Maryland, United States, 21224