Status:
COMPLETED
Exercise Dose and Nonalcoholic Fatty Liver Disease
Lead Sponsor:
Washington University School of Medicine
Conditions:
Non-alcoholic Fatty Liver Disease (NAFLD)
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
The purpose of this research is to provide a better understanding of how exercise (walking) affects non-alcoholic fatty liver disease (NAFLD) in overweight people. NAFLD, which is common in obese peop...
Detailed Description
Non-alcoholic fatty liver disease (NAFLD) affects about 33% of adults in the United States. The prevalence of NAFLD is four to five times higher in obese than lean persons and is associated with insul...
Eligibility Criteria
Inclusion
- Age 18-65 with Nonalcoholic Fatty Liver Disease as determined by MRS
Exclusion
- Medical History
- Diabetes
- Heart Disease
- Asthma/Lung disease
- Injury that prevents exercise
- Social history
- Drinking
- More than one drink per day
- Binge drinking on the weekends (more than 3 or 4 drinks per weekend day)
- Smoking
- It's OK if they were a previous smoker, but they need to have quit more than 6 months ago
- Exercise
- They must exercise less than one hour per week
- Medications: must be on stable regimen of ANY medication for at least 3 months
- Beta-Blockers
- Lipid/cholesterol lowering medications:
- Oral hypoglycemics (anti-diabetes medications - some like metformin are indicated for pre-diabetes)
- Hormone replacement therapy
- If the woman is pre-menopausal, it is OK if she is on birth control as long as she has been on it over 3 months
- Weight history
- Weight \<300 lbs
- BMI 30 to 45
- Weight stable - \<10lbs weight loss or gain in the last 3 months
Key Trial Info
Start Date :
May 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2011
Estimated Enrollment :
33 Patients enrolled
Trial Details
Trial ID
NCT00771108
Start Date
May 1 2006
End Date
April 1 2011
Last Update
September 7 2011
Active Locations (1)
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1
Washington University School of Medicine
St Louis, Missouri, United States, 63110