Status:
TERMINATED
In Vivo Imaging of Pigmentary Disorders by Reflectance Confocal Microscopy
Lead Sponsor:
Massachusetts General Hospital
Conditions:
Vitiligo
Melasma
Eligibility:
All Genders
20-70 years
Brief Summary
This is a pilot study to evaluate the findings of the Reflectance Confocal Microscopy when performed in cutaneous pigmentary disorders, such as vitiligo, melasma, post-inflammatory hyper-pigmentation ...
Eligibility Criteria
Inclusion
- Subjects 20-70 years of age.
- Clinical diagnosis of vitiligo, melasma, post-inflammatory hypo or depigmentation or post-inflammatory hyperpigmentation.
- Willing and able to understand and sign informed consent.
- Able to complete study and comply with study procedures.
Exclusion
- Use of topical therapies such as corticosteroids, protopic, hydroquinone and azelaic acid within the past 2 months.
- Use of light therapy such as narrow-band-UVB, PUVA or laser within the past 2 months.
- Intake of medications that can cause pigmentary changes within the past year. Examples are:
- Antimalarials (chloroquine, hydroxychloroquine)
- Chemotherapeutics (bleomycin, busulfan, doxorubicin, daunorubicin, fluorouracil, cyclophosphamide, and carmustine)
- Heavy metals (gold, silver, bismuth, and mercury)
- Tetracyclines (including minocycline, doxycycline)
- Amiodarone
- Azidothymidine
- Clofazimine
- Clinically significant abnormal findings or conditions (other than the pigmentary disorder), which might, in the opinion of the Principal Investigator, interfere with study evaluations or pose a risk to subject safety during the study.
- Subjects who are known to be pregnant or planning a pregnancy.
Key Trial Info
Start Date :
August 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
July 1 2010
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00771355
Start Date
August 1 2008
End Date
July 1 2010
Last Update
March 30 2011
Active Locations (1)
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1
Clinical Unit for Research Trials in Skin
Boston, Massachusetts, United States, 02114