Status:
COMPLETED
Effects of Insulin Treatment on Postprandial Platelet Activation in Patients With Non-insulin-dependent Diabetes Mellitus (NIDDM)
Lead Sponsor:
Karolinska Institutet
Conditions:
Type 2 Diabetes Mellitus
Postprandial Hyperglycemia
Eligibility:
All Genders
Up to 70 years
Phase:
PHASE4
Brief Summary
The postprandial phase in diabetic patients is characterized by a rapid increase in blood glucose levels, increase in platelet aggregation, LDL oxidation and over production of thrombin. The aim of t...
Detailed Description
Each patient is admitted in the fasting state, on 3 different occasions . Blood glucose levels are normalized using intravenous infusion of insulin aspart , to a blood glucose level of 6-7 mmol/l. 15 ...
Eligibility Criteria
Inclusion
- Type II Diabetes Mellitus.
- Antecubital forearm veins allowing technically good sampling for platelet studies.
- HbA1c 6-9 % (Mono-S method).
- Below 70 years
Exclusion
- History of a cardiovascular disease; Ischemic heart disease, Stroke, Peripheral vascular disease.
- Acute or chronic renal or liver disease
- Contraindication to insulin treatment
- Treatment with Glitazones, Sulphonylurea, antiplatelet drugs,
- Thrombocytopenia \<150 X109/l.
Key Trial Info
Start Date :
May 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2011
Estimated Enrollment :
18 Patients enrolled
Trial Details
Trial ID
NCT00771693
Start Date
May 1 2007
End Date
July 1 2011
Last Update
May 27 2022
Active Locations (1)
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1
Department of Medicine, Clinical pharmacology Unit, Karolinska University Hospital, Solna.
Stockholm, Sweden, SE 171 76