Status:
COMPLETED
A Study to Evaluate the Effect of Analgesics on a Walking Model of Knee Pain (0000-105)(COMPLETED)
Lead Sponsor:
Merck Sharp & Dohme LLC
Conditions:
Osteoarthritis
Eligibility:
All Genders
45+ years
Phase:
PHASE1
Brief Summary
This study will evaluate a walking model of osteoarthritis for use in testing of new therapeutic agents. The primary hypothesis is that participants treated with Naproxen or Ultracet will have lower P...
Eligibility Criteria
Inclusion
- Has osteoarthritis of the knee and primary source of pain is knee
- Females must not be pregnant or nursing and must agree to use birth control throughout the study
- Is willing to limit alcohol and caffeine intake
- Is willing to abstain from smoking during study visits
- Must be able to walk on a treadmill at a pace of at least 1 mile/hour
Exclusion
- Has a medical/arthritic disease that would interfere with evaluation
- Is unable to take naproxen or Ultracet
- Has congestive heart failure or angina
- Has a history of stroke
- Has a history of uncontrolled high blood pressure
- Has a history of cancer
- Regularly uses a walker or cane
Key Trial Info
Start Date :
June 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2008
Estimated Enrollment :
22 Patients enrolled
Trial Details
Trial ID
NCT00772967
Start Date
June 1 2008
End Date
November 1 2008
Last Update
November 20 2015
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