Status:
WITHDRAWN
Aliskiren and Renin Inhibition in Diastolic Heart Failure
Lead Sponsor:
Texas Tech University Health Sciences Center
Conditions:
Diastolic Heart Failure
Eligibility:
All Genders
21-70 years
Phase:
NA
Brief Summary
This study is being conducted to compare the effects that 2 different combinations of heart failure medications have on the levels of certain blood markers which cause and/or worsen heart failure. Add...
Detailed Description
Our main hypothesis is that in contrast to non Hispanic whites, the degree of RAAS system activation is more pronounced in Mexican Americans with diastolic HF and consequently their response to RAAS i...
Eligibility Criteria
Inclusion
- Chronic stable diastolic HF documented by clinical diagnosis and echocardiogram within the last 2 years
- NYHA classes I-III, symptomatically stable (for \>1month)
- Age 21-70 years
- Either of Hispanic ethnicity (Mexican American origin) or non-Hispanic white
- Patients on ACE inhibitor therapy (lisinopril)
- Blood pressure \>100/75 mmHg
- Adequate birth control
- Patients seen in TTUHSC Cardiology or Internal Medicine clinic for at least two visits since January 2008
Exclusion
- Acute coronary syndrome (within the last month).
- Recent acute diastolic or systolic HF (within the last month)
- Pancreatic disease
- Renal artery stenosis
- Pregnancy
- History of angioedema
- Severe hypotension (systolic BP\<90mmHg or mean arterial pressure \<65mmHg)
- Hyperkalemia (defined by K+\>5 mEq/L)
- Chronic Kidney Disease (Stage 3 and above)
- Systolic dysfunction (ejection fraction below 50%)
- Ethnicity other than Mexican American or non-Hispanic white
Key Trial Info
Start Date :
September 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2009
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00773084
Start Date
September 1 2008
End Date
August 1 2009
Last Update
May 12 2015
Active Locations (1)
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1
Texas Tech University Health Sciences Center
Lubbock, Texas, United States, 79430