Status:

COMPLETED

Deep Brain Stimulation in Patients With Dystonia

Lead Sponsor:

University of California, San Francisco

Conditions:

Dystonia

Eligibility:

All Genders

7-80 years

Phase:

NA

Brief Summary

The purpose of this study is to evaluate the safety and effectiveness of deep brain stimulation (DBS) of the subthalamic nucleus (STN)for primary dystonia.

Detailed Description

Dystonia is an uncommon brain disorder in which there is abnormal muscle tone producing twisting, writhing movements and abnormal postures. It is associated with abnormal electrical activity in two gr...

Eligibility Criteria

Inclusion

  • Refractory primary dystonia diagnosed by a movement disorders neurologist
  • Severe functional impairment despite optimal medical management, including failed botulinum toxin therapy
  • Age 7-80 years (UCSF patients) and 18-80 (VA patients)

Exclusion

  • Patients considered at high risk for elective neurosurgery because of co-morbid conditions
  • Brain MRI showing extensive brain atrophy or small vessel ischemic disease
  • Pregnancy
  • Inability to tolerate awake microelectrode-guided neurosurgery
  • Inability to follow up with post-operative study visits
  • Inability to speak or read English
  • Patients with a score of 4.5 or lower on the BFMDRS movement scale
  • Patients with Secondary dystonia

Key Trial Info

Start Date :

June 1 2008

Trial Type :

INTERVENTIONAL

Allocation :

ACTUAL

End Date :

February 1 2015

Estimated Enrollment :

9 Patients enrolled

Trial Details

Trial ID

NCT00773604

Start Date

June 1 2008

End Date

February 1 2015

Last Update

February 19 2019

Active Locations (2)

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Page 1 of 1 (2 locations)

1

San Francisco Veterans Administration Medical Center

San Francisco, California, United States, 94121

2

University of California, San Francisco

San Francisco, California, United States, 94143