Status:
COMPLETED
Efficacy and Safety Study of Apremilast (CC-10004) in Subjects With Moderate-to-Severe Plaque-Type Psoriasis (Core Study)
Lead Sponsor:
Amgen
Conditions:
Psoriasis
Plaque-type Psoriasis
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
The purpose of this study was to test if the drug apremilast was safe, if it helped improve psoriasis, and how well the participants tolerated it.
Detailed Description
This study fully explored the extent of treatment benefit achieved with doses of apremilast up to 30 mg by mouth (PO) twice daily (BID) with treatment duration for up to 6 months. In addition, it was ...
Eligibility Criteria
Inclusion
- Understand and voluntarily sign an informed consent form
- ≥18 years of age at the time of signing the informed consent form
- Able to adhere to the study visit schedule and other protocol requirements.
- Diagnosis of chronic, stable plaque psoriasis at least 6 months prior to screening as defined by:
- PASI (Psoriasis Area and Severity Index) score ≥ 12
- Body Surface Area (BSA) ≥ 10%
- Candidate for photo/systemic therapy
- In good health as judged by the investigator, based on medical history, physical examination, 12-lead electrocardiogram (ECG), serum chemistry, hematology, immunology, and urinalysis
- Meet all laboratory criteria as defined per protocol
- Females of childbearing potential (FCBP) must have a negative urine pregnancy test at screening (Visit 1). In addition, sexually active FCBP must agree to use TWO of the following adequate forms of contraception methods. A FCBP must agree to have pregnancy tests every 4 weeks while on study medication
- Males (including those who have had a vasectomy) must agree to use barrier contraception (latex condoms) when engaging in reproductive sexual activity with FCBP while on study medication and for 84 days after taking the last dose of study medication
Exclusion
- History of clinically significant disease (as determined by the investigator)
- Pregnant or breastfeeding
- History of active mycobacterial infection within 3 years
- History of Human Immunodeficiency Virus (HIV) infection
- Congenital and acquired immunodeficiencies
- Hepatitis B surface antigen positive or Hepatitis B core antibody positive at screening
- Antibodies to Hepatitis C at screening
- Malignancy or history of malignancy except for treated \[i.e., cured\] basal-cell skin carcinomas
- Any condition, including the presence of laboratory abnormalities, that places the subject at unacceptable risk if he/she were to participate in the study or confounds the ability to interpret data from the study
- Psoriasis flare within 4 weeks of screening
- Topical therapy within 2 weeks of randomization
- Systemic therapy for psoriasis within 4 weeks of randomization
- Use of phototherapy within 4 weeks of randomization \[(i.e., Ultraviolet (UVB), Psoralens and long-wave ultraviolet radiation (PUVA)\]
- Adalimumab, etanercept, efalizumab or infliximab within 12 weeks of randomization
- Alefacept within 24 weeks of randomization
- Investigational drug within 4 weeks of randomization, or 5 pharmacokinetic/pharmacodynamic half lives, if known (whichever is longer)
- Prolonged sun exposure or use of tanning booths or other ultraviolet light sources
Key Trial Info
Start Date :
September 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 20 2015
Estimated Enrollment :
352 Patients enrolled
Trial Details
Trial ID
NCT00773734
Start Date
September 1 2008
End Date
May 20 2015
Last Update
May 7 2020
Active Locations (35)
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1
Associates In Research Inc
Fresno, California, United States, 93720
2
Dermatology Associates
Los Angeles, California, United States, 90045
3
Stanford University School of Medicine
Redwood City, California, United States, 94063
4
Atlantic Skin & Cosmetic Surgery Group, PC
Wilmington, Delaware, United States, 19810