Status:
COMPLETED
Transdisciplinary Studies of CBT for Anxiety in Youth: Child Anxiety Treatment Study
Lead Sponsor:
University of Pittsburgh
Collaborating Sponsors:
National Institute of Mental Health (NIMH)
Conditions:
Generalized Anxiety Disorder
Separation Anxiety Disorder
Eligibility:
All Genders
9-14 years
Phase:
NA
Brief Summary
The purpose of this study is to investigate neurobehavioral, affective, and social processes that may influence and predict treatment response in pediatric anxiety disorders.
Detailed Description
This protocol proposes to study neurobehavioral and social correlates of treatment response in 200 youth (ages 9-13) with general anxiety disorder (GAD), separation anxiety disorder (SAD), and social ...
Eligibility Criteria
Inclusion
- Clinical diagnosis of DSM-IV diagnosis of Generalized Anxiety Disorder (GAD), Separation Anxiety Disorder (SAD), and Social Phobia (SP)
Exclusion
- 1\. IQ below 70 as assessed by the Wechsler Abbreviated Scale of Intelligence (WASI).
- 2\. Requires current ongoing treatment with psychoactive medications including anxiolytics and antidepressants.
- 3\. Acutely suicidal or at risk for harm to self or others. 4. Any motor impairments or eye-hand coordination problems 5. Persons not suited for fMRI procedures including those who have cardiac pacemakers, neural pacemakers, surgical clips in the brain or blood vessels, surgically implanted metal plates, screws or pins, cochlear implants, IUDs, metal braces, or other metal objects in their body, especially in the eye. Dental fillings do not present a problem. Plastic or removable dental appliances do not require exclusion. Pregnancy, determined by pregnancy tests on post-menarcheal females.
- 6\. History of head injury. 7. Neuromuscular or neurological disorder 8. Vision that is 20/40 and below that cannot be corrected by glasses or contacts.
- Specific exclusion criteria for anxious participants includes:
- Current comorbid diagnosis of: primary major depressive disorder (MDD) (subjects who have primary GAD with co-morbid MDD that is secondary in terms of course and functional impact are not excluded), obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), conduct disorder, substance abuse or dependence
- Lifetime diagnosis of autism or Asperger syndrome, bipolar disorder, psychotic depression, schizophrenia, or schizoaffective disorder.
- Specific exclusion criteria for controls includes:
- Any current or lifetime DSM-IV diagnosis.
- Having a parent with current or lifetime DSM-IV diagnosis of anxiety or mood disorders.
Key Trial Info
Start Date :
October 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2014
Estimated Enrollment :
194 Patients enrolled
Trial Details
Trial ID
NCT00774150
Start Date
October 1 2008
End Date
July 1 2014
Last Update
July 18 2014
Active Locations (1)
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1
University of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15213