Status:
TERMINATED
Antiepileptic Drugs and Vascular Risk Markers
Lead Sponsor:
Thomas Jefferson University
Collaborating Sponsors:
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Subarachnoid Hemorrhage
Eligibility:
All Genders
Phase:
NA
Brief Summary
The purpose of this study is to determine if certain seizure medications raise levels of cholesterol and other blood components which could increase the risk of heart attacks and strokes.
Detailed Description
There is some evidence that certain seizure medicines may raise levels of cholesterol and other blood components which could increase the risk of heart attacks and strokes, however, more research is n...
Eligibility Criteria
Inclusion
- Acute subarachnoid hemorrhage, Hunt-Hess Grades I-IV
- Within 48 hours of admission
Exclusion
- Grade V subarachnoid hemorrhage
- Being treated with a lipid-lowering agent
- Contraindication to phenytoin, valproate, or levetiracetam (e.g. history of allergy to one of these agents)
- Contraindication to receiving no antiepileptic drug treatment (e.g. history of pre-existing epilepsy, seizure activity on admission EEG)
Key Trial Info
Start Date :
April 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2012
Estimated Enrollment :
52 Patients enrolled
Trial Details
Trial ID
NCT00774306
Start Date
April 1 2009
End Date
June 1 2012
Last Update
December 18 2017
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