Status:
COMPLETED
Sex and Obesity: Effects on Heart Failure Study
Lead Sponsor:
Washington University School of Medicine
Collaborating Sponsors:
The Foundation for Barnes-Jewish Hospital
Conditions:
Obesity
Heart Failure
Eligibility:
All Genders
20-65 years
Brief Summary
Sex has a major impact on myocardial metabolism and blood flow. In those without heart failure men's hearts tend to use proportionally more glucose and women's hearts use more fat and have higher bloo...
Eligibility Criteria
Inclusion
- Inclusion criteria
- Heart failure (HF) and a systolic ejection fraction \<45% per a recent echocardiogram report)
- Nonischemic HF New York Heart Association Class II-III
- Ambulatory
- Able to give informed consent
- On a stable medical regimen including the standard-of-care HF medications (i.e., a beta-blocker, ACE-inhibitor or angiotensin receptor blocker \[ARB\])
- Exclusion criteria
- Participants who were pregnant or lactating
- Actively losing weight
- Nonsedentary (performing aerobic exercise \> 30 minutes x 3 times/week)
- Those who have more than Class I hypertension
- Those who require alterations in beta-blocker or ACE or ARB-inhibition medication
- Those with hypertrophic, constrictive, or restrictive cardiomyopathies
- Those unable to lie flat in the PET scanner
- Severe major organ system dysfunction (other than heart failure)
- Significant coronary artery disease by catheterization
- Those unable to give informed consent
Exclusion
Key Trial Info
Start Date :
February 1 2000
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
April 2 2011
Estimated Enrollment :
19 Patients enrolled
Trial Details
Trial ID
NCT00776035
Start Date
February 1 2000
End Date
April 2 2011
Last Update
May 3 2024
Active Locations (1)
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1
Washington University School of Medicine
St Louis, Missouri, United States, 63110