Status:
COMPLETED
A Study of Avastin (Bevacizumab) in Combination With Thoracic Radiation and Chemotherapy in Patients With Advanced Non-Squamous Non-Small Cell Lung Cancer.
Lead Sponsor:
Hoffmann-La Roche
Conditions:
Non-Squamous Non-Small Cell Lung Cancer
Eligibility:
All Genders
18+ years
Phase:
PHASE1
Brief Summary
This single arm study will evaluate the feasibility of treatment with 2 dose levels of Avastin in combination with concurrent thoracic radiation and chemotherapy in patients with locally advanced unre...
Eligibility Criteria
Inclusion
- adult patients, \>= 18 years of age;
- non-squamous non-small cell lung cancer, locally advanced and unresectable;
- ECOG performance status 0 or 1;
- no prior thoracic or head and neck radiation;
- no prior surgical resection for current lung cancer.
Exclusion
- malignancies other than non-small cell lung cancer within 2 years prior to inclusion, except for basal cell cancer of the skin, squamous cancer of the skin, or cancer in situ of the cervix;
- prior systemic therapy for non-small cell lung cancer;
- clinically significant cardiovascular disease;
- history of \>= grade 2 hemoptysis;
- current or recent use of aspirin (\>325mg/day) or full dose anticoagulants or thrombolytic agents for therapeutic purposes.
Key Trial Info
Start Date :
April 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2010
Estimated Enrollment :
1 Patients enrolled
Trial Details
Trial ID
NCT00776698
Start Date
April 1 2009
End Date
February 1 2010
Last Update
November 2 2016
Active Locations (5)
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1
Amsterdam, Netherlands, 1007 MB
2
Groningen, Netherlands, 9713 GZ
3
Maastricht, Netherlands, 6229 HX
4
Aberdeen, United Kingdom, AB9 2ZB