Status:
COMPLETED
Ocular Growth Factors Profile in Proliferative Retinopathies Before and After Intravitreal Bevacizumab
Lead Sponsor:
Ophthalmological Association Edelweiss
Collaborating Sponsors:
University of Cologne
Conditions:
Proliferative Diabetic Retinopathy
Age Related Macular Degeneration
Eligibility:
All Genders
20+ years
Phase:
PHASE2
Brief Summary
Aims of the trial: Establishing the profile of the growth factors and other mediators of angiogenesis in different ocular fluids (aqueous humour, vitreous gel and ocular liquid in vitrectomized eyes),...
Eligibility Criteria
Inclusion
- age over 20 years
- nondiabetic patients requiring cataract surgery or vitrectomy for different posterior segment nonproliferative disorders - controls groups
- diabetic patients asking ophthalmologic treatments for different degrees of decreasing of visual acuity - diabetic groups
- diabetic patients requiring cataract surgery or vitrectomy - diabetic groups
- age related macular degeneration patients asking ophthalmologic treatments for different degrees of decreasing of visual acuity - age related macular degeneration groups
- age related macular degeneration patients requiring cataract surgery or vitrectomy - age related macular degeneration groups
Exclusion
- patients under the age of 20 years
- patients that did not accept and signed the informed consent of the trial
- patients that received any anti-VEGF therapy for any proliferative or inflammatory ocular disease
- patients that received any type of intraocular injection with any pharmaceutical agent
- patients with any clinical type of malignancy in their pathologic antecedents
- patients with recent penetrating trauma (less than 1 year old)
- patients operated for different ocular disorders requiring combination with antimetabolites (ex. 5-FU or Mitomycin C with trabeculectomy)
- patients with intraocular inflammations or infections or other pathologies that contraindicate open globe surgery or intraocular injections with anti-VEGF blockers
Key Trial Info
Start Date :
October 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2010
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT00776763
Start Date
October 1 2008
End Date
December 1 2010
Last Update
July 22 2011
Active Locations (1)
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1
Railway Universitary Hospital
Iași, Romania, 700506