Status:
COMPLETED
Thrombolysis and Deferoxamine in Middle Cerebral Artery Occlusion
Lead Sponsor:
Germans Trias i Pujol Hospital
Collaborating Sponsors:
Fundació Institut Germans Trias i Pujol
Conditions:
Ischemic Stroke, Acute
Eligibility:
All Genders
18-80 years
Phase:
PHASE2
Brief Summary
Iron overload has been associated with greater brain injury in ischemia/reperfusion experimental stroke models and ischemic stroke patients, especially in those treated with thrombolytic treatment. De...
Eligibility Criteria
Inclusion
- Age 18-80 years old
- Acute Ischemic Stroke on the middle cerebral artery territory
- Treatment with iv tPA in the first 3 hours from symptoms onset
Exclusion
- Modified Rankin Scale more or equal to 2
- Infectious, inflammatory, neoplastic or hematologic disease
- Anemia (Hto\<34% or Hb\<10g/dl)
- Previous renal failure
- Previous treatment with oral iron supplement
- Minor stroke (NIHSS less than 4), lacunar or posterior territory
- Alcohol consumption (more than 40mg/Kg)
- Pregnancy
- Participation in other clinical trials
Key Trial Info
Start Date :
September 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2011
Estimated Enrollment :
62 Patients enrolled
Trial Details
Trial ID
NCT00777140
Start Date
September 1 2008
End Date
December 1 2011
Last Update
August 8 2022
Active Locations (4)
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1
Hospital Universitari Germans Trias i Pujol
Badalona, Barcelona, Spain, 08916
2
Hospital Clínico Universitario de Santiago de Compostela
Santiago de Compostela, La Coruña, Galicia, Spain, 15706
3
Hospital Universitari Josep Trueta
Girona, Spain, 17007
4
Hospital Universitario de la Princesa
Madrid, Spain, 28006