Status:
UNKNOWN
Weight Loss Effects on Heart and Blood Vessel Function in Obesity
Lead Sponsor:
University of Adelaide
Collaborating Sponsors:
Royal Adelaide Hospital
Conditions:
Obesity
Eligibility:
MALE
18-65 years
Phase:
PHASE2
PHASE3
Brief Summary
Obesity is a growing epidemic and is associated with an increased risk of heart attack and stroke. The investigators know that obesity leads to abnormalities in how the blood vessels and the heart fun...
Eligibility Criteria
Inclusion
- Obese Caucasian men age 18-65 years, who are non smokers, and consuming 2 or fewer standard alcoholic drinks per day (on average over the past 5 years) will be recruited.
- Obesity, for the purposes of this study, is defined by a BMI \> 30 and a waist circumference \> 102 cm.
- Caucasian men only are enrolled because the cut-off points for the definition of obesity vary significantly by race.
Exclusion
- Men are excluded if they have any previously diagnoses or symptomatic atherosclerotic disease, or are taking any cardiovascular medication.
- Men with known gallstones, history of gout, or any contraindication to MRI are also excluded.
Key Trial Info
Start Date :
April 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT00782262
Start Date
April 1 2005
Last Update
October 31 2008
Active Locations (1)
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1
University of Adelaide, Royal Adelaide Hospital
Adelaide, South Australia, Australia, 5000