Status:
COMPLETED
Exploratory Study of Coronary Flow Reserve Measurements, a Non-Invasive Method for Coronary Function Measurements
Lead Sponsor:
AstraZeneca
Conditions:
Atherosclerosis
Inflammatory Activity in Coronary Arteries
Eligibility:
All Genders
45-75 years
Phase:
EARLY_PHASE1
Brief Summary
The aim of this study is to investigate whether the non-invasive ultrasound method for assessment of coronary blood flow, transthoracic Doppler echocardiography-coronary flow reserve (TTDE-CFR), can b...
Eligibility Criteria
Inclusion
- Males aged 45-75 years or females aged 60-75 years inclusive
- Carotid and/or femoral atherosclerotic plaque, as assessed by carotid ultrasound examination within the last 5 years
- Abnormal concentrations of lipids or lipoproteins in the blood
- Provision of signed informed consent
Exclusion
- Treatment with statins or other lipid-lowering drugs, e.g. fibrates, nicotinic acid, cholesterol absorption inhibitor, within the last 6 months before randomisation
- Current smoking or snuff tobacco use
- Major CV event (myocardial infarction (MI), stroke/ transitory ischemic attack (TIA), Acute Coronary Syndrome (ACS), revascularisation) within the last 6 months before randomisation
- Symptomatic carotid stenosis, atrioventricular (AV) block, QT-prolongation, atrial fibrillation, sinus node disease (such as sick sinus syndrome or symptomatic bradycardia), chronic obstructive pulmonary disease (COPD) or asthma
Key Trial Info
Start Date :
October 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 1 2009
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT00783042
Start Date
October 1 2008
End Date
May 1 2009
Last Update
June 30 2009
Active Locations (1)
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1
Research Site
Gothenburg, Sweden