Status:
TERMINATED
Aspirin and Antiretroviral Therapy in HIV Infected Patients
Lead Sponsor:
Hennepin Healthcare Research Institute
Conditions:
HIV Infection
Eligibility:
All Genders
18-60 years
Phase:
PHASE2
Brief Summary
The purpose of this study is to examine the effects of HIV treatment (antiretroviral therapy) and aspirin use on risk for cardiovascular disease among HIV infected persons.
Detailed Description
Cardiovascular disease is now a major health concern among persons with HIV infection. Our general hypothesis is that HIV-mediated inflammation and injury to vascular surfaces up-regulates thrombotic ...
Eligibility Criteria
Inclusion
- HIV-infected (by positive HIV Ab or detectable HIV RNA level)
- No ART for at least previous 3 months
- Ready to start or re-start ART (regimen pre-chosen by patient and provider)
Exclusion
- Age \< 18 years, or \>60 years
- Pregnancy
- Current aspirin use
- Presence of known atherosclerotic CVD determined by:
- Previous myocardial infarction
- Significant coronary atherosclerosis by angiography
- Coronary revascularization procedure (coronary stent or surgical bypass)
- Previous cerebral vascular accident (stroke)
- Ischemic cardiomyopathy
- Carotid stenosis (\>25% narrowing by carotid ultrasound)
- Aortic aneurysm
- Symptomatic peripheral vascular disease (claudication)
- Surgical revascularization procedure of peripheral vessels
- Hospitalization (within prior 2 weeks of study entry)
- Concurrent self-limited bacterial infections (does not include chronic viral infections)
- Clinical or pathologic diagnosis of systemic vasculitis
- Active drug or alcohol use
Key Trial Info
Start Date :
October 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2010
Estimated Enrollment :
22 Patients enrolled
Trial Details
Trial ID
NCT00783614
Start Date
October 1 2008
End Date
June 1 2010
Last Update
November 21 2017
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Hennepin County Medical Center
Minneapolis, Minnesota, United States, 55415