Status:
COMPLETED
In Vivo Effects of C1-esterase Inhibitor on the Innate Immune Response During Human Endotoxemia
Lead Sponsor:
Radboud University Medical Center
Conditions:
Endotoxemia
Inflammation
Eligibility:
MALE
18-35 years
Phase:
NA
Brief Summary
Excessive inflammation is associated with tissue damage caused by over-activation of the innate immune system. This can range from mild disease to extreme conditions such as multiple organ failure (MO...
Detailed Description
Rationale: There is an unmet need for novel therapeutic agents focused on the complications caused by acute and excessive activation of the innate immune response after injury. As this activation res...
Eligibility Criteria
Inclusion
- Healthy male volunteers (18-35 years old)
Exclusion
- Relevant medical history
- Drug-, nicotine-, alcohol abuses
- Tendency towards fainting
- Hyper- or hypotension
Key Trial Info
Start Date :
November 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2009
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00785018
Start Date
November 1 2008
End Date
August 1 2009
Last Update
April 22 2011
Active Locations (1)
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1
Radboud University Nijmegen Medical Centre
Nijmegen, Netherlands, 6500HB