Status:
COMPLETED
Non-Invasive Ventilation Versus Continuous Positive Airway Pressure in Cardiogenic Pulmonary Edema: a Multicentre Study
Lead Sponsor:
University of Monastir
Conditions:
Cardiogenic Pulmonary Edema
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
Non-invasive ventilation (NIV) has become now a widely used treatment modality in ICU and emergency services to deal with respiratory failure.1 NIV has the potential to improve ventilatory assistance ...
Detailed Description
Cardiogenic pulmonary edema is defined as an increase of hydrostatic pressure in the pulmonary microcirculation resulting from postcapillaire hypertension. The direct consequence is extravasation of ...
Eligibility Criteria
Inclusion
- All patients aged \>18 years and having acute respiratory failure caused by CPE.
- The origin of cardiogenic pulmonary edema is defined according to the history and clinical presentation, the chest X-ray and / or data of echocardiography when they are available with a serum BNP\> 100pg/ml.
- The acute respiratory failure is defined by the existence of clinical signs and / or arterial gas parameters:
- sweats and / or agitation and / or signs of struggle and /or drowsiness
- dyspnea with respiratory rate \> 35/min,
- a blood oxygen saturation ≤ 90% by air.
Exclusion
- Instability of the hemodynamic state (severe rhythm disturbances, hypotension with systolic arterial pressure \<50 mmHg, need for inotropic drugs).
- The need for immediate endotracheal intubation.
- Contraindications to the use of a facial or nasal mask (or facial skin lesion).
- History of recent gastrointestinal surgery or pseudo obstruction.
- Refusal of participation or non-cooperation of the patient.
Key Trial Info
Start Date :
January 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2008
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT00785174
Start Date
January 1 2005
End Date
July 1 2008
Last Update
November 5 2008
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