Status:
COMPLETED
Evaluation of Variable Pressure Support Ventilation in the Therapy of Acute Lung Injury
Lead Sponsor:
Technische Universität Dresden
Conditions:
Acute Lung Injury
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
Variable pressure support during assisted spontaneous breathing (noisy PSV) has been shown to improve the respiratory function in experimental acute lung injury (ALI). We aimed at comparing the effect...
Eligibility Criteria
Inclusion
- age 18 to 75 yrs
- 150 mmHg \< PaO2/FIO2 \< 300 mmHg
- mechanical ventilation with PSV or BIPAP
- less than 15 days of mechanical ventilation
- at least 20% of minute ventilation originated from spontaneous breathing
Exclusion
- BMI \> 35
- esophageal disease
- neuromuscular disease
- instable thorax
- pneumothorax
- head trauma
- brain injury
- increased intracranial pressure
- agitation
- increased need for vasoactive drugs
- chronic lung disease
- acute coronary disease
- participation in another clinical trial within the last 4 weeks at enrollment
- Interruption criteria:
- acute change of mental status
- SaO2 \< 92%
- pHa \< 7.30
- respiratory rate \> 30 or \< 6 /min
- dyspnea
- diaphragm/thorax antagonism
- diaphoresis
- abnormal use of respiratory muscles
- increase of the heart rate above 120% of baseline or absolute value \< 60 or \> 130 /min
- mean arterial pressure above 120% of baseline or absolute value \< 70 or \> 110 mmHg
Key Trial Info
Start Date :
July 1 2009
Trial Type :
INTERVENTIONAL
End Date :
September 1 2012
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00786292
Start Date
July 1 2009
End Date
September 1 2012
Last Update
September 5 2012
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
University Clinic Carl Gustav Carus, Technical University Dresden
Dresden, Germany, 01307