Status:
COMPLETED
Diaphragmatic Function in Ventilated Patients
Lead Sponsor:
University Hospital, Montpellier
Conditions:
Critically Ill
Eligibility:
All Genders
18-85 years
Brief Summary
Animal studies showed that controlled mechanical ventilation (CMV) can induce dysfunction of the diaphragm, resulting in an early-onset and progressive decrease in diaphragmatic force-generating capac...
Eligibility Criteria
Inclusion
- Invasive mechanical ventilation (tracheally intubated or tracheotomized) less than 48h.·
- Duration of mechanical ventilation for at least 72h.·
- Subject itself or its next of kin has given written informed consent
Exclusion
- Patient is less than 18 years or more than 85 years of age·
- The attending physician refuses to allow enrollment·
- The patient refuses informed consent
- Next of kin is unavailable or refuses informed consent·
- Pregnant or breast-feeding female.
- A pregnancy test will be performed in all female patients less than 60 years of age.·
- Any contraindication to use cervical magnetic stimulation (mechanical cardiac assist device …).·
- Presence or suspicion of prior diaphragm injury or chronic disease·
- Presence or suspicion of a central nervous system (CNS) disorder, including (but not limited to): CNS infarction, bleeding, tumor, or infection
Key Trial Info
Start Date :
March 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 1 2010
Estimated Enrollment :
55 Patients enrolled
Trial Details
Trial ID
NCT00786526
Start Date
March 1 2008
End Date
July 1 2010
Last Update
October 30 2013
Active Locations (2)
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1
Department of Anesthesia and Critical Care (DAR B)
Saint-Eloi University Hospital of Montpellier, Montpellier, France, 34295
2
Service de Pneumologie et Réanimation
Groupe Hospitalier La Pitié-Salpêtrière-Paris, Paris, France, 75013