Status:
WITHDRAWN
Evaluation of Skeletal Muscle Lipid Content by Magnetic Resonance Spectroscopy
Lead Sponsor:
University of Minnesota
Collaborating Sponsors:
National Center for Research Resources (NCRR)
Conditions:
Healthy
Eligibility:
All Genders
18-45 years
Brief Summary
Type 2 diabetes is a growing public health issue and one component of Type 2 diabetes is 'insulin resistance" - the ability of insulin to work less well. The skeletal muscle is one of the largest user...
Detailed Description
High intramyocellular lipid (IMCL) content in skeletal muscle has been correlated to insulin resistance in obese subjects. Yet, endurance athletes have high intramyocellular lipid content and very low...
Eligibility Criteria
Inclusion
- Age range will be from age 18 to 45. We will be limiting the upper age range because increased age is associated with sarcopenia and alteration of fiber type.
- We will define the lean trained group by a BMI of \< 24 kg/m2. We will define the overweight group as BMI \> 26 25 kg/m2.
- The subjects should be participating in regular running exercise (\> 30 min/day, ≥ 5 days/week).
- Weight must be stable \[+/- 5 pounds\] for at least the three months prior to the study for all participants.
Exclusion
- The subjects must not be on medications that may affect lipid levels, specifically lipid lowering agents, birth control pills, or diuretics.
- The subjects should not be on a high fat diet (\> 45% fat) as measured by a screening questionnaire.
- The subject must not have any contraindications to magnetic resonance imaging.
Key Trial Info
Start Date :
January 1 2010
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 1 2014
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00786578
Start Date
January 1 2010
End Date
January 1 2014
Last Update
October 24 2014
Active Locations (1)
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1
Univeresity of Minnesota
Minneapolis, Minnesota, United States, 55455