Status:
COMPLETED
Role of T-cells in Post-Menopausal Osteoporosis
Lead Sponsor:
Atlanta VA Medical Center
Collaborating Sponsors:
Emory University
Conditions:
Osteoporosis
Eligibility:
All Genders
18-55 years
Brief Summary
This is an observational study of women undergoing surgical menopause to determine whether T-cells play an important role in the etiology of post-menopausal osteoporosis. Subjects will examined before...
Detailed Description
Estrogen (E) deficiency is a major cause of post-menopausal osteoporosis. The mechanisms by which E deficiency causes osteoporosis has been recently linked to regulation of two key osteoclastic cytoki...
Eligibility Criteria
Inclusion
- Women between the age of 18-55, pre-menopausal by history (regular spontaneous menstrual bleeding every 21-35 days) or documented FSH \<10, no current estrogen therapy, undergoing hysterectomy with (ovx) or without ovariectomy (control group) for benign gynecologic disease (fibroid uterus, endometriosis, dysfunctional uterine bleeding, chronic pelvic pain) or for prophylaxis against ovarian cancer (BRCA positive).
Exclusion
- History of an active cancer including breast and uterine cancer, treatment with chemotherapy or glucocorticoids
- History of an immune deficiency syndrome including HIV infection
- History of severe anemia with hematocrit \< 25.
Key Trial Info
Start Date :
December 1 2006
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2012
Estimated Enrollment :
19 Patients enrolled
Trial Details
Trial ID
NCT00787904
Start Date
December 1 2006
End Date
December 1 2012
Last Update
December 13 2016
Active Locations (1)
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1
Emory University
Atlanta, Georgia, United States, 30322