Status:
COMPLETED
Cognitive Effects of Inhalational Versus Intravenous General Anesthesia in the Elderly
Lead Sponsor:
Duke University
Collaborating Sponsors:
US Department of Veterans Affairs
Conditions:
Lumbar Spondylosis
Cervical Spondylosis
Eligibility:
All Genders
65+ years
Phase:
NA
Brief Summary
The purpose of this research is to determine if post-operative cognition will be better if the general anesthesia for surgery is done with an inhaled (gas through a breathing tube) or intravenous (med...
Detailed Description
A prospective randomized pre-test post-test design will be used. After obtaining informed consent, patients will be randomized to either: 1) Inhalational anesthesia with isoflurane or 2) Total intrave...
Eligibility Criteria
Inclusion
- patients (aged 65 years or older) scheduled for elective spine or major joint replacement (total hip or total knee arthroplasty) at Duke University Medical Center or the Durham VA Medical Center
Exclusion
- not fluent in English and able to comprehend the English language
- have severe visual or auditory handicaps
- Carry a diagnosis of dementia or score \< 18 on the Mini-Mental State Examination (MMSE) as calculated from the Modified Mini-Mental State (3MS) (see D4 below)
- have allergies to eggs, propofol, isoflurane, fentanyl, remifentanil, or pregabalin
Key Trial Info
Start Date :
November 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2013
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT00788008
Start Date
November 1 2008
End Date
December 1 2013
Last Update
March 26 2015
Active Locations (2)
Enter a location and click search to find clinical trials sorted by distance.
1
Duke University Medical Center
Durham, North Carolina, United States, 27710
2
VAMC
Durham, North Carolina, United States, 27710