Status:
COMPLETED
Study of Cerebral Function in Patients With Chronic Hepatitis C Infection (HCV/CNS)
Lead Sponsor:
Aarhus University Hospital
Conditions:
Hepatitis C, Chronic
Cognition Disorders
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
Patients with HCV infection often suffer from chronic fatigue, depression and reduced cognition, even before evolving severe liver fibrosis, liver cirrhosis and hepatic encephalopathy. It is currentl...
Eligibility Criteria
Inclusion
- Chronic HCV infection with genotype 1, 2, 3 or 4.
- Age \> 18 and \<60
- Liver biopsy or fibroscan performed within last 5 years
- Signed informed consent form.
Exclusion
- Liver biopsy showing liver pathology not due to HCV infection.
- Liver cirrhosis or severe liver fibrosis
- Former antiviral HCV treatment (for included HCV patients).
- HIV and/or Hepatitis B virus infection.
- Alcohol or drug abuse within the last 2 years.
- Neutropenia, anemia or thrombocytopenia.
- Clinical signs of non-compensated liver pathology.
- Moderate to severe cardiopulmonary disease (NYHA score 1 or above)
- Creatinine clearance \< 80mL/min.
- Pregnancy.
- Ferromagnetic implants
- Significant somatic disease affecting the central nervous system (somatic/neurologic disease)
- Head trauma resulting in unconsciousness \> 5min
- Schizophrenia or other psychotic disorders
Key Trial Info
Start Date :
November 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2012
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT00788918
Start Date
November 1 2008
End Date
November 1 2012
Last Update
January 11 2013
Active Locations (1)
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1
Department of Infectious Diseases, Aarhus University Hospital, Skejby
Aarhus, Jylland, Denmark, 8200