Status:
UNKNOWN
Trial of the Effects of Remote Preconditioning on the Tissue Metabolism During Exercise and Ischemia
Lead Sponsor:
The Hospital for Sick Children
Conditions:
Ischemia
Eligibility:
All Genders
16-40 years
Phase:
PHASE2
Brief Summary
Previously, the preconditioning signaling pathways have been studied on molecular level or in animal model. By using MR spectroscopy and imaging in a dynamic human model of preconditioning, we will ha...
Detailed Description
Ischemic preconditioning is a mechanism that protects tissue against ischemia-reperfusion injury. The protective effect of preconditioning is induced by short periods (1-5 minutes) of non-lethal ische...
Eligibility Criteria
Inclusion
- Healthy male and female volunteers
- Post-pubescent non-athletes between the ages of \>16 and \<40 years of age.
Exclusion
- Older than 40 year old.
- Younger than 16 year old.
- Major medical condition
- Illness, surgery or medical intervention in the last 48 hours.
- Diabetes Mellitus
- Caffeine intake in the last 48 hours
- Athlete (more than 5 training sessions per week)
Key Trial Info
Start Date :
November 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2014
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00791206
Start Date
November 1 2008
End Date
June 1 2014
Last Update
December 16 2013
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