Status:
COMPLETED
Short-term Atorvastatin's Effect on Acute Kidney Injury Following Cardiac Surgery
Lead Sponsor:
Vanderbilt University Medical Center
Conditions:
Acute Kidney Injury
Post-Operative Delirium
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Aim1a: Statin naive patient's scheduled for cardiac surgery will be randomized to 80mg atorvastatin or placebo on the day prior to surgery and then 40mg daily thereafter until hospital discharge to te...
Eligibility Criteria
Inclusion
- open heart surgery
Exclusion
- acute coronary syndrome with troponin leak or unrelenting angina
- liver dysfunction (transaminases 2x normal)
- history of myopathy or liver dysfunction on prior statin therapy
- use of potent CYP3A4 inhibitors such as antifungal azoles, macrolide antibiotics, HIV protease inhibitors, and nefazodone.
- pregnancy or breast feeding
- cyclosporine use
- dialysis
- history of kidney transplant
- fibrate users who cannot stop fibrate use.
Key Trial Info
Start Date :
July 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2014
Estimated Enrollment :
653 Patients enrolled
Trial Details
Trial ID
NCT00791648
Start Date
July 1 2009
End Date
December 1 2014
Last Update
September 16 2019
Active Locations (1)
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1
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37212