Status:
WITHDRAWN
Airway Pressure Release Ventilation (APRV) Compared to ARDSnet Ventilation
Lead Sponsor:
University of Tennessee, Chattanooga
Conditions:
Acute Lung Injury
Adult Respiratory Distress Syndrome
Eligibility:
All Genders
18-85 years
Phase:
PHASE2
Brief Summary
Traditional modes of ventilation have failed to improve patient survival. Subsequent observations that elevated airway pressures observed in traditional forms of ventilation resulted in barotrauma and...
Detailed Description
Low volume ventilation may increase number of ventilatory free days and may improve overall patient survival. While reducing mean airway pressure has reduced barotrauma and improved patient survival, ...
Eligibility Criteria
Inclusion
- All patients admitted to the Internal Medicine service at the Baroness Erlanger Hospital of the University of Tennessee College of Medicine with hypoxia (O2 saturation \< 93%) and pulmonary distress, will be screened for study participation.
- Patients displaying all the following clinical criteria: acute onset of respiratory failure; hypoxia defined as a PaO2/FiO2 ratio of \< 300 Torr; pulmonary capillary wedge pressure less or equal than 18 mm Hg, and/or no clinical evidence of left sided heart failure; and chest x-ray with diffuse bilateral pulmonary infiltrates.
Exclusion
- Patients receiving conventional volume ventilation with or without PEEP for \> 6 hours prior to study enrollment
- Patient's family or surrogate unwilling to give informed consent
- Patients requiring sedation or paralysis for effective ventilation
- Patients known pulmonary embolus within 72 hours of study enrollment
- Patients with close head injuries or evidence of increased intracranial pressure
- Patients with burns over 30% of total body surface area
- Pulmonary capillary wedge pressure greater than 18 mm Hg
- CVP \> 15 cm H2O
- Patients with B type Naturetic peptide levels \> 1000
- Patients with prior history of dilated cardiomyopathy with EF \< 25%
- Patients receiving chronic outpatient peritoneal or hemodialysis
- Patients with severe liver disease (as defined by Child-Pugh class C)
- AIDS patients
Key Trial Info
Start Date :
November 2 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 2 2020
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00793013
Start Date
November 2 2020
End Date
November 2 2020
Last Update
November 4 2020
Active Locations (1)
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1
James A. Tumlin, MD
Chattanooga, Tennessee, United States, 37403