Status:
COMPLETED
Pilot Trial of Naltrexone for Obesity in Women With Schizophrenia
Lead Sponsor:
Yale University
Collaborating Sponsors:
Ethel F. Donaghue Women's Health Investigator Program at Yale
Conditions:
Obesity
Schizophrenia
Eligibility:
FEMALE
18-70 years
Phase:
NA
Brief Summary
The purpose of this clinical trial is to find out how effective low dose oral naltrexone is on reducing body weight when compared to placebo in women with schizophrenia and schizoaffective disorder.
Eligibility Criteria
Inclusion
- Women between the ages of 18 to 70
- Meet DSM-IV (Diagnostic and Statistical Manual version IV) criteria for schizophrenia or schizoaffective disorder based on SCID (Structured Clinical Interview for the DSM-IV) interview
- Overweight, as defined with a BMI of equal to or greater than 27 kg/m² and continuing weight gain in the past year above 2% of previous years total body weight
- Be on a stable dose of antipsychotic medication; i.e. at least one month with no dosage change, and two months from an antipsychotic switch; 5) Deemed to be symptomatically stable by the clinical staff in the last two months
Exclusion
- Meet criteria for current alcohol or other substance dependence, opioid use for any reason or positive urine drug screen for opiates
- A history of dementia, mental retardation or other neurological disorder that may interfere with study ratings
- Not capable of giving informed consent for participation in this study
- Ongoing pregnancy
- Known sensitivity to naltrexone
- A medical disorder that is known to cause obesity
- Use of sibutramine, topiramate, amphetamines or over the counter weight remedies
- Impaired liver functions (greater than 3 times the upper limit of normal)
- Diagnosed with polycystic ovary syndrome
- Currently being treated with insulin
- Current use of Depo-Provera or any natural/synthetic hormone treatment known to cause significant weight gain
Key Trial Info
Start Date :
December 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2010
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT00793780
Start Date
December 1 2008
End Date
November 1 2010
Last Update
October 6 2016
Active Locations (1)
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1
Connecticut Mental Health Center
New Haven, Connecticut, United States, 06519