Status:
COMPLETED
Magnetic Resonance Imaging of Aortic Aneurysm Instability
Lead Sponsor:
University of Edinburgh
Collaborating Sponsors:
British Heart Foundation
Conditions:
Aortic Aneurysm
Eligibility:
All Genders
40+ years
Phase:
PHASE2
PHASE3
Brief Summary
Abdominal aortic aneurysm (AAA) is a progressive enlargement of the aorta, the largest blood vessel in the body. It is at risk of bursting when it is usually fatal. Currently the risk of the AAA burst...
Detailed Description
Abdominal aortic aneurysms (AAA) have a prevalence of \~5% and when ruptured carry a mortality rate of \~90%. The pathophysiology of AAA encompasses a range of poorly understood biomechanical and biol...
Eligibility Criteria
Inclusion
- AAA measuring \>40mm in AP diameter on ultrasound scanning
- Age \>40 years (patients younger than this with AAA may have a connective tissue disorder and a different aetiology to their disease)
- Considered to be suitable for standard infra-renal open surgical repair
Exclusion
- Patients who are not deemed to be fit for open surgical repair
- Patients who are deemed to be suitable for a stent graft performed by the radiologists rather than the standard operation
- Contraindication to MRI scanning identified from MRI Safety Questionnaire (see attached)or claustrophobia
- Age \<40 years
- Patients requiring emergent repair such that there is insufficient time available to complete the protocol
- Patients refusing to give consent
- Patients unable to give consent
- Pregnant women (contrast is teratogenic in animals)
- Intercurrent illness (may confound the results)
- Patients with a systemic inflammatory disorder or underlying malignancy
- Patients who require an emergency operation such that there is insufficient time to complete the study protocol
- Renal dysfunction (Creat \>250 or eGFR\<25)
- Hepatic dysfunction (Child's grade B or C)
Key Trial Info
Start Date :
November 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2010
Estimated Enrollment :
29 Patients enrolled
Trial Details
Trial ID
NCT00794092
Start Date
November 1 2008
End Date
June 1 2010
Last Update
June 21 2021
Active Locations (1)
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1
University of Edinburgh/Royal Infirmary of Edinburgh
Edinburgh, Midlothian, United Kingdom, Eh16 4SA