Status:
ENROLLING_BY_INVITATION
Dynamic MRI and Quantitative MR CSF Flow Studies in Craniovertebral Junction Anomalies
Lead Sponsor:
University of Michigan
Conditions:
Chiari Malformations
Eligibility:
All Genders
12+ years
Brief Summary
The purpose of this study is to decide which position of the neck affects cerebral spinal fluid (CSF) flow between the spinal cord and the brain. CSF is a fluid that flows up and down your spinal cord...
Detailed Description
In this study, subjects will have a dynamic cervical magnetic resonance imaging (MRI) of the craniovertebral junction (CVJ) coupled with CSF flow studies. The studies will assess changes in CSF flow v...
Eligibility Criteria
Inclusion
- Healthy volunteers must be 18 yrs of age or older.
- Patients w/Chiari 1 or CVJ malformations aged 12 yrs or older,
- Able to cooperate in flexing and extending their neck within the cervical spine coil used for MR Imaging.
- Pediatric patients will be included only if they can cooperate for additional sequences done for the study who don't require sedation or any form of anesthesia.
Exclusion
- Patients who are medically unstable or cannot voluntarily flex or extend their necks.
- Patients who have hardware in the head or necks which are incompatible with MR imaging.
- Patient requiring any form of sedation which can lead to compromise of the airway with maneuvers described above.
- History of prior head trauma or history of neurological conditions which can result in altered CSF dynamics.
Key Trial Info
Start Date :
July 15 2012
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2026
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT00795080
Start Date
July 15 2012
End Date
December 1 2026
Last Update
December 29 2025
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