Status:
COMPLETED
A Study Of The Usage Of Statins In A Community Heart Failure Population
Lead Sponsor:
St Vincent's University Hospital, Ireland
Collaborating Sponsors:
University of Dublin, Trinity College
University College Dublin
Conditions:
Heart Failure
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
Inflammation and fibrosis may be important contributors to worsening heart failure. As well as lowering cholesterol, statins are also known to reduce inflammatory markers such as C-reactive protein wh...
Detailed Description
Heart Failure (HF) remains a major public health problem. Despite significant advances in the pharmacological management of this condition, the high mortality associated with heart failure remains a c...
Eligibility Criteria
Inclusion
- Mild to moderate HF (NYHA class II-III) of any aetiology and documented left ventricular systolic dysfunction (LVEF \< 45%) by echocardiography within 3 months of randomization. These patients were clinically stable, on optimal HF medical therapy which had remained unaltered for at least four weeks prior to recruitment. All had normal fasting total cholesterol.
Exclusion
- Those receiving lipid lowering agents; those with absolute or relative contraindications to statins; those with known chronic inflammatory conditions; patients with medical conditions requiring anti-inflammatory or immuno-suppressive therapies.
Key Trial Info
Start Date :
May 1 2003
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2008
Estimated Enrollment :
56 Patients enrolled
Trial Details
Trial ID
NCT00795912
Start Date
May 1 2003
End Date
January 1 2008
Last Update
November 21 2008
Active Locations (1)
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1
Heart Failure Unit, St Vincents University Hospital
Dublin, Co Dublin, Ireland, 4