Status:
UNKNOWN
Effects of Cosopt on IOP and on Ocular Diastolic Perfusion Pressure
Lead Sponsor:
University of Turin, Italy
Conditions:
Glaucoma
Eligibility:
All Genders
45-65 years
Phase:
PHASE4
Brief Summary
Hypothesis: Studies suggest that patients with low diastolic velocity and high resistivity index in the ophthalmic artery had more progressive visual fields, the investigators hypothesize therefore th...
Detailed Description
Fifty patients with primary open angle glaucoma (POAG) treated with Xalatan for whom the monotherapy was not sufficient to achieve the target IOP, will be included in the study. Non responders were de...
Eligibility Criteria
Inclusion
- POAG patients with a pattern deviation score (or its equivalent) ranging from 2.5 dB to 6.0 dB will be included in the study. This will ensure that patients with early/mid-stage glaucoma will be homogeneously collected; avoids advanced glaucoma in which OBF may behave as a different disease state.
- Best-corrected visual acuity will be of 0.5 or better with an ametropia \<5D - Dioptric transparency, non smokers.
- Age will be between 45 and 65 years.
Exclusion
- n
- Normal tension glaucoma, ocular hypertension, cardiovascular and/or metabolic diseases (known to affect blood flow, as diabetes and polycythemia)
- Visual field defects other than glaucoma; use of vasoactive and/or anti-hypertensive drugs (systemic beta-blocker), use of acetazolamide
- Hypersensibility and/or contraindications to any of the molecules studied
- Previous ocular surgery
- Pregnant or nursing women and use of one of drugs for erectile dysfunction
Key Trial Info
Start Date :
December 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 1 2009
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT00796198
Start Date
December 1 2008
End Date
July 1 2009
Last Update
November 25 2008
Active Locations (5)
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1
University of Bari
Bari, Italy, 70124
2
University of Chieti
Chieti, Italy, 66100
3
University of Genova
Genova, Italy, 16132
4
University of Siena
Siena, Italy, 53100