Status:
TERMINATED
Hypoxia-inducible Factor-1 (HIF-1) Regulated Circulating Angiogenic Cells (CACs) Recruitment in Burn Wound Healing
Lead Sponsor:
Johns Hopkins University
Collaborating Sponsors:
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Wound Healing
Burns
Eligibility:
All Genders
14-75 years
Phase:
NA
Brief Summary
This research is being done to increase knowledge about wound healing and different factors that may affect healing in burn patients.
Detailed Description
Burn injuries represent a major public health problem, requiring medical attention for more than one million Americans annually. Despite therapeutic advances, non-healing burn wounds and excessive sca...
Eligibility Criteria
Inclusion
- Recruitment of patients at the Johns Hopkins Regional Burn Center for study will be based upon the following clinical criteria:
- Second degree scald burn of 10 cm2
- Age between 14 to 75 years
- Burn area equal or less than 95% of Burn Surface Area (BSA)
- Body temperature between 98.5 and 101 degree F
- Informed consent for enrolment into study
- Spanish speaking patients will be included when we have a Spanish consent form available.
Exclusion
- First and third degree burn wounds
- Hemodynamic instability (SBP below 100, Heart Rate (HR) over 100, urine output less than 30 ml/hour
- Area of burn over 20% of BSA
- Hypothermia T\<98.5 or Hyperthermia T\>101 degree F
- Urine output less than 30 ml/hour
- Serum albumin less than 3 mg/ml.
- Subjects weighing less than 50 kg.
Key Trial Info
Start Date :
December 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2014
Estimated Enrollment :
41 Patients enrolled
Trial Details
Trial ID
NCT00796627
Start Date
December 1 2006
End Date
April 1 2014
Last Update
September 29 2017
Active Locations (1)
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1
Johns Hopkins Bayview Medical Center
Baltimore, Maryland, United States, 21224