Status:
UNKNOWN
Study to Evaluate Nosocomial Transmission of Influenza
Lead Sponsor:
University Hospitals, Leicester
Conditions:
Influenza
Eligibility:
All Genders
18-40 years
Brief Summary
The purpose of this study is to investigate whether influenza can be reliably transmitted from children to susceptible contacts in a health care setting. The goal is to develop a transmission that can...
Detailed Description
CHildren with influenza infection presenting to ED will be identified by RAT. Healthy healthcare worker subjects will expose themselves and perform specific activities with the child. subjects will b...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- Infected Children
- Age \< 16 years
- Parents or legal guardians willing to give informed written consent
- Presenting with a febrile illness confirmed as influenza by near patient rapid antigen testing
- Healthy volunteers
- Willing to give informed written consent
- Exclusion criteria
- Children
- No parents or legal guardians able to give informed consent
- Healthy volunteers
- known allergy to oseltamivir or zanamivir
- presence of underlying condition or concomitant therapy requiring dose alteration of oseltamivir (severe renal or hepatic failure; methotrexate and probenecid)
- underlying immunosuppressive disorder
- known galactose intolerance
- underlying chronic medical condition known to increase risk of influenza-related complications (including asthma, chronic pulmonary airways disease, chronic cardiovascular disease, diabetes mellitus, chronic neurological disorder)
- inability or contraindication to collection of nasal swabs
- previous influenza vaccination within 2 years
- current smoker
- pregnancy
Exclusion
Key Trial Info
Start Date :
December 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
May 1 2009
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT00798421
Start Date
December 1 2008
End Date
May 1 2009
Last Update
November 26 2008
Active Locations (1)
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1
University Hospitals Leicester
Leicester, Leics, United Kingdom, LE1 5WW