Status:
COMPLETED
Mitral Valve Prolapse (MVP) - France Study
Lead Sponsor:
French Cardiology Society
Collaborating Sponsors:
Leducq Foundation
Institut National de la Santé Et de la Recherche Médicale, France
Conditions:
Mitral Valve Prolapse
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This prospective nation-wide (France) study aims to search for susceptibility genes in MVP using a genome wide analysis and comparing results obtained in 1000 patients with MVP and 1000 non-MVP subjec...
Detailed Description
Two MVP populations will be defined in that study, either with the classical Barlow (myxomatous) disease or the fibroelastic degenerescence (thin and redundant leaflets). MVP adult patients (\> 18 ye...
Eligibility Criteria
Inclusion
- Inclusion criteria for MVP patients :
- Male or female subject ≥18 years
- Affiliation to the French social insurance system
- Written informed consent
- Idiopathic MVP defined by the presence of criteria 1) and 2) OR of criterion 3) :
- Echographic MVP \> 2 mm on the left ventricular parasternal long-axis view
- Echographic myxomatous valve (thickness \> 4 mm) or significant mitral regurgitation (\> 2 + using color Doppler)
- History of mitral valve surgery for pure mitral regurgitation due to MVP (myxomatous or fibroelastic deficiency) with available detailed operative report.
- Exclusion criteria :
- Presence of heart disease causing MVP (rheumatic, HCM…)
- Syndromic disease (Marfan, Ehlers-Danlos…)
- Inclusion criteria for healthy subject :
- Male or female subject ≥40 years
- Absence of MVP or absence of mitral valve dystrophy
- Caucasian
Exclusion
Key Trial Info
Start Date :
December 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2011
Estimated Enrollment :
1179 Patients enrolled
Trial Details
Trial ID
NCT00799565
Start Date
December 1 2008
End Date
July 1 2011
Last Update
July 14 2011
Active Locations (26)
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1
Hôpital Sud
Amiens, France, 80054
2
Clinique Saint Augustin
Bordeaux, France, 33074
3
Hôpital Ambroise Paré
Boulogne, France, 92104
4
Hôpital de la Cavale Blanche
Brest, France, 29609