Status:
COMPLETED
Circadian Ocular Perfusion Pressure and Ocular Blood Flow
Lead Sponsor:
Alcon Research
Conditions:
Glaucoma
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
The purpose of this study was to compare the short term effects of two intraocular pressure (IOP) lowering medications on ocular perfusion pressure (OPP), ocular blood flow, intraocular pressure, and ...
Eligibility Criteria
Inclusion
- Sign Informed Consent.
- Diagnosis of open-angle glaucoma in at least one eye.
- Requires more than one IOP-lowering medication.
- IOP measurements at Screening, Safety, and Eligibility/Period 1 Baseline Visits as specified in protocol.
- Able to discontinue all IOP-lowering medication prior to Eligibility Visit and for 4 weeks between treatment periods.
- Willing to complete all required study visits.
- Other protocol-defined inclusion criteria may apply.
Exclusion
- Female of child-bearing potential if pregnant, lactating, or not using highly effective birth control measures.
- Severe central visual field loss in either eye.
- Previous glaucoma surgery in the study eye.
- Intraocular surgery in the study eye within 3 months prior to the Screening Visit.
- Wears contact lenses.
- Allergy/hypersensitivity to study medication.
- Cannot safely discontinue use of glucocorticoid medication.
- Uses medication that could affect IOP or blood pressure.
- Recent use of high-dose aspirin.
- Bronchial asthma or severe chronic obstructive pulmonary disease.
- Diabetic retinopathy.
- Any abnormality preventing reliable tonometry.
- Any severe illness or condition unsuitable for the study, in the opinion of the investigator.
- Other protocol-defined exclusion criteria may apply.
Key Trial Info
Start Date :
February 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2012
Estimated Enrollment :
35 Patients enrolled
Trial Details
Trial ID
NCT00800540
Start Date
February 1 2009
End Date
January 1 2012
Last Update
March 22 2013
Active Locations (1)
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1
Contact Alcon Call Center at 1-888-451-3937 For Trial Locations
Fort Worth, Texas, United States, 76134