Status:
COMPLETED
Kinetics of Biomarkers in Acute Pyelonephritis
Lead Sponsor:
University Hospital, Geneva
Conditions:
Pyelonephritis
Eligibility:
FEMALE
18+ years
Brief Summary
The objective of this study is to explore the kinetics of biomarkers in 30 adult female patients with uncomplicated acute pyelonephritis.
Detailed Description
We will measure c-reactive protein, procalcitonin, pyuria and a new blood biomarker (Signature TM) everyday till normalization of these markers in 30 adult female patients with uncomplicated acute pye...
Eligibility Criteria
Inclusion
- \> 18 years
- Flank/loin pain or tenderness, or both and fever \> 38°C during the last 48 hours and pyuria
Exclusion
- Pregnancy
- Presence of indwelling catheters
- Known polycystic kidney disease or any malformation of the urinary tract, or single kidney; renal transplant recipients; acute or chronic renal failure requiring dialysis
- Recent discharge from hospital (during the last 10 days); ongoing antibiotic treatment
- Known severe immunosuppression: Receiver of solid-organ or hematopoietic stem cells transplants; neutropenia ( \< 1 G neutrophils / L); chronic (more than 14 days) use of systemic glucocorticoids (\>10 mg/d of prednisone); active use of immunosuppressive therapy for the treatment of auto-immune or inflammatory disease; HIV infection with \< 350 CD4+ cells / ml or unknown CD4+ status
- Pyelonephritis initially identified as complicated: obstruction of urinary tract, urinary stone; history of renal infection in the last 15 days
- Patient with severe sepsis or septic shock
Key Trial Info
Start Date :
December 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
April 1 2010
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT00805181
Start Date
December 1 2008
End Date
April 1 2010
Last Update
October 7 2010
Active Locations (1)
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1
Geneva University Hospitals
Geneva, Canton of Geneva, Switzerland, 1211